Soundgrain is a graphical interface where users can draw and edit trajectories to control granular sound synthesis. Soundgrain is written with Python/WxPython and uses Pyo as its audio engine.

Soundgrain is a graphical interface where users can draw and edit trajectories to control granular sound synthesis. Soundgrain is written with Python/WxPython and uses Pyo as its audio engine.

FluidSynth is a real-time software synthesizer based on the SoundFont 2 specifications and has reached widespread distribution. FluidSynth itself does not have a graphical user interface, but due to its powerful API several applications utilize it and it has even found its way onto embedded systems and is used in some mobile apps.
Features:
- Cross platform support (Linux, macOS and Windows to name a few)
- SoundFont 2 support
- SoundFont 3 support (vorbis-compressed SF2)
- Realtime effect control using SoundFont 2.01 modulators
- Playback of MIDI files
- Shared library which can be used in other programs
- Built in command line shell

QSynth is a fluidsynth GUI front-end application written in C++ around the Qt framework using Qt Designer.

FluidPatcher is a performance-oriented interface for FluidSynth built using wxpython to create a simple GUI that allows live editing, selecting, and playing of patches. A patch is a collection of settings such as soundfont presets for each MIDI channel, control-change/sysex messages to send when the patch is selected, and midi router or effects settings. Groups of patches are stored in banks, which are saved as human-readable and -editable YAML files. This allows a musician to easily create complex combinations of synthesizer settings ahead of time and switch between them on the fly during a performance.
SonicBirth is an AudioUnit designing MacOS application. The first in its category, it allows users to build their own AudioUnit plugins, either by working with existing circuits or by creating circuits completely from scratch. SonicBirth is also a free AudioUnits package, as it comes bundled with a set of plugins designed for standalone use as plugins as well as pre-constructed circuits to modify or build upon for creating new plugins. Whether you’re looking for traditional eqs, compressors, and reverbs, or softsynths, distortion, and filters, etc., SonicBirth allows you unprecedented freedom and creativity over your sound.

eSpeak is a compact open source Linux and Windows speech synthesizer for English and other languages. eSpeak uses a “formant synthesis” method. This allows many languages to be provided in a small size. The speech is clear, and can be used at high speeds, but is not as natural or smooth as larger synthesizers which are based on human speech recordings.
eSpeak is available as:
- A command line program (Linux and Windows) to speak text from a file or from stdin.
- A shared library version for use by other programs. (On Windows this is a DLL).
- A SAPI5 version for Windows, so it can be used with screen-readers and other programs that support the Windows SAPI5 interface.
- eSpeak has been ported to other platforms, including Android, Mac OSX and Solaris.
Amsynth is an easy-to-use software synth with a classic subtractive synthesizer topology.
- Dual oscillators (sine / saw / square / noise) with hard sync
- 12/24 dB/oct resonant filter (low-pass / high-pass / band-pass / notch)
- Mono / poly / legato keyboard modes
- Dual ADSR envelope generators (filter & amplitude)
- LFO which can modulate the oscillators, filter, and amplitude
- Distortion and reverb

amsynth.github.io
github.com/amsynth
en.wikipedia.org/wiki/Amsynth
padthv1 is an old-school polyphonic additive synthesizer with stereo fx; it is based on the PADsynth algorithm by Paul Nasca, as a special variant of additive synthesis.
Features:
- a pure stand-alone JACK client with JACK-session, NSM (Non Session management) and both JACK MIDI and ALSA MIDI input support;
- a LV2 instrument plug-in URI: padthv1.sourceforge.net/lv2

drumkv1 is an old-school all-digital drum-kit sampler synthesizer with stereo fx.
Features:
- a pure stand-alone JACK client with JACK-session, NSM (Non Session management) and both JACK MIDI and ALSA MIDI input support;
- a LV2 instrument plug-in. URI: drumkv1.sourceforge.net/lv2

samplv1 is an old-school all-digital polyphonic sampler synthesizer with stereo fx.
Features:
- a pure stand-alone JACK client with JACK-session, NSM (Non Session management) and both JACK MIDI and ALSA MIDI input support;
- a LV2 instrument plug-in. (URI: samplv1.sourceforge.net/lv2)

samplv1
synthv1 is an old-school all-digital 4-oscillator subtractive polyphonic synthesizer with stereo fx.
Features:
- a pure stand-alone JACK client with JACK-session, NSM (Non Session management) and both JACK MIDI and ALSA MIDI input support;
- a LV2 instrument plug-in. (URI: synthv1.sourceforge.net/lv2)

Cecilia is an audio signal processing environment aimed at sound designers. Cecilia mangles sound in ways unheard of. Cecilia lets you create your own GUI using a simple syntax. Cecilia comes with many original built-in modules and presets for sound effects and synthesis.

Frinika is a free, complete music workstation software for Linux, Windows, Mac OSX and other operating systems running Java. It features a sequencer, soft-synths, real-time effects and audio recording.

ZynAddSubFX is a fully featured open source software synthesizer capable of making a countless number of instruments …
zynaddsubfx.sourceforge.net
zynaddsubfx.sourceforge.net/download
VST version
en.wikipedia.org/wiki/ZynAddSubFX